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Focal and Salvage Cryotherapy

Cryotherapy for Recurrent Prostate Cancer after Radical Radiotherapy or Salvage Cryotherapy

This is an information guide for men who are either considering treatment, or are being treated, for recurrent prostate cancer by cryosurgery.


Cryosurgery is a technique designed to destroy the prostate gland in a minimally invasive manner (i.e. there is no need for incisions), utilising cryogenic gas. It can be used for men with prostate cancer confined to the gland and also in men where the prostate cancer is locally advanced (i.e. the can has spread to the outer edge of the gland). It can be used as focal treatment (first choice treatment in patients with small volume cancers localised in one part of the gland) or as salvage treatment after recurrence of the disease after radical radiotherapy. In Europe, it is mainly used for men who have recurrent prostate cancer following radiotherapy treatment (this also includes brachytherapy, a procedure whereby small radioactive seeds are implanted into the prostate), although recently it starts to become popular as focal treatment as well.

How cryosurgery works


Although minimally invasive, it is a procedure that requires expertise in prostatic ultrasound scanning, cryoneedle placement and experience in monitoring ice-ball formation.

 


Cryosurgery


Cryosurgery is also referred to as cryoablation or cryotherapy. It is a technique that involves using a carefully controlled freezing process as the surgery, instead of a scalpel. Cryogenic gases are circulated through tiny cryoprobes or needles within the prostate, which are introduced through the skin. The concept of using extreme cold to treat prostate cancer was developed in the 1960s, when liquid nitrogen was used to freeze the prostate in a rather unsophisticated manner, but its use was limited by high complication rates and unsatisfactory results.
However, the introduction of liquid argon and helium gas technology, linked to sophisticated and accurate prostate ultrasound scanning techniques, has allowed cryosurgery to develop, using a procedure that minimises complications and improves results.

During the process, the prostate is frozen to -140°C by argon gas, then warmed, using helium gas. Fine cryoneedles are introduced through the perineum, the area between the scrotum and anus, under ultrasound control and using a template for accuracy.
There are no incisions.Temperature needles are used to monitor the process precisely, particularly around the sphincter muscle, which is situated below the prostate, and also the wall of the rectum.A warming catheter is used throughout the procedure, to protect the inner lining of the urethra and sphincter muscle area.


Selection of patients

Cryosurgery is most commonly used for men with prostate cancer that has recurred after radiotherapy treatment (including brachytherapy) when it remains confined to the prostate gland. It has also been used to treat patients with locally advanced disease.
Cryosurgery is best used in situations where the initial (pre-radiotherapy treatment) PSA was less than 15ng/ml and the Gleason grade of the pathology is grade 7 or below.
Men who have severe urinary symptoms, or those who have had previous prostatic surgery may not be suitable, although this will be assessed at the initial consultation by a questionnaire and urinary flow tests. A preliminary telescope examination, under local anaesthetic, and bladder pressure monitoring, also under local anaesthetic, may be necessary as part of the initial assessment.
Some men may have a large prostate gland, which can make cryosurgery difficult. It is usually possible to shrink the gland, using hormonal agents which are often used in prostate cancer treatment. This is discussed at the initial consultation if necessary.


Advantages of cryosurgical treatment

Cryosurgery is minimally invasive and can be carried out either as a day-patient case or with an overnight stay. There is little in the way of post-operative pain, although bruising is quite common around the site of the cryoneedles in the perineal area.
Most men are up and about quickly following the procedure, although it is advisable not to take strenuous exercise during the period whilst the catheter is in place.
There is usually no need for a transfusion, as blood loss is minimal. Cryosurgery can be repeated at a later stage if necessary.
Cryosurgery can be used for men who have a recurrence of prostate cancer post-radiotherapy (including brachytherapy). It can also be used in men who are unsuitable for major surgery or radiotherapy.
Focal cryosurgery, a procedure in which the tumour within the gland is identified and treated, has been introduced in some centres, particularly in the United States. The technique is still under review, although early results are promising, especially with regard to lower impotence rates.


Disadvantages of cryosurgical treatment


The technique has a higher risk of impotence than other treatments, as the nerves involved in creating an erection lie just behind the prostate gland, adjacent to the rectum, and are included in the freeze process.
However, recovery can occur over 12 months or so.
Patients can be instructed in the use of medications such as Viagra, injection therapy and vacuum erection devices, if necessary.
ATTENTION: this is a fact only for patients with recurrent cancer post-radiotherapy.

Pre-operation

On admission to hospital, the procedure is discussed both with the surgeon and with the anaesthetist. The procedure can be carried out under either a general or a local anaesthetic (i.e. spinal). Patients are usually given a simple enema to clear the lower bowel.


The procedure takes between 1-2 hours.
Intravenous antibiotics are given to guard against the risk of infection.
Cryoneedles are introduced through the perineum under ultrasound guidance and a computer technique, utilising a template grid. Full temperature monitoring is carried out and the urethra is warmed to preserve the sphincter muscle.

 


Post-operation

When the patient awakes, he will have a urethral catheter draining through his penis. This allows swelling of the prostate to settle down in the 14 days or so following the cryosurgery. There will be dressings around the perineum, to minimise bruising. The patient is returned to the ward and later instructed on how to use the catheter. The patient is discharged with dressings, which are changed daily following a bath. Simple painkillers may be necessary to relieve discomfort, although this is usually quite minimal.


Complications and side effects

  • Constipation is quite common following any surgical procedure and is usually managed by simple means such as gentle laxatives and increased fluid intake.
  • Bruising of the perineal area is common and is managed by simple dressings and avoiding prolonged periods of standing in the two weeks following cryosurgery.
  • Blood in the urine is very common following catheter insertion and removal and can occur intermittently for several weeks after cryosurgery.
  • Longer term problems can include urinary incontinence, particularly during coughing and sneezing (stress incontinence).
  • Very rarely, damage can occur to the rectum (fistula).This complication may need further surgery to resolve.
  • Patients are discharged following catheter removal, with simple pads to minimise discomfort and are given full instructions in pelvic floor exercises.

Impotence


This is a common problem following cryosurgical treatment when cancer recurs after radical radiotherapy treatment and will have been discussed in detail before consideration of cryosurgery. Recovery is possible over twelve months or so. There are various ways of helping with this problem and these are usually discussed before the operation with the surgery and cryosurgery specialist.

Post-cryosurgery and removal of the catheter

Men can return to normal activities following catheter removal. It is advisable to continue with the pelvic floor exercises.

Pelvic floor exercises
  • To do these exercises effectively, you need to first relax your abdominal and buttock muscles.
  • To identify and correctly contract the pelvic floor muscles, imagine that you are trying to hold back bowel movements or from passing gas.
  • During this action, you should feel the opening of the rectum contract.


  • Tighten the muscles for 3-5 seconds and then relax for 6-10 seconds. Repeat this sequence 20-25 times.
  • Do the set of 20-25 contractions 3-4 times daily.
  • During the first week of the programme, perform the exercises whilst lying down, but later while sitting and standing. After the initial learning period, perform the exercises when you need them, i.e. just before sneezing, coughing or straining.


Summary

Cryosurgery is an effective treatment for men who have evidence of recurrence of prostate cancer following treatment utilising external beam radiotherapy or brachytherapy and has been reviewed and approved by the National Institute of Clinical Excellence (NICE).However, staging investigations are essential to check that the disease remains confined to the prostate gland.
Cryosurgery is a technique requiring considerable skill in ultrasound scanning of the prostate and needle placement. In addition, as with all surgical techniques, the best results are obtained by surgeons who have carried out a large number of these procedures. This should be discussed with the surgeon before making a final decision with regard to treatment.


Commonly asked questions

  • Will I be given hormone treatment prior to the cryosurgery? If yes, why? If not, why not?
  • How long does the operation take?
  • Will I have a blood transfusion?
  • Will you be targeting any organ other than my prostate?
  • Will you attempt to do nerve-sparing cryosurgery if possible? In your experience, how successful is this procedure?
  • What are your results in respect of impotence and incontinence?
  • How long will I be in hospital?
  • Will I have much pain after cryosurgery and how will it be controlled?
  • If I go home with a catheter, when will it be removed and by whom?
  • How soon is my follow-up appointment after discharge?
  • If I have continence problems after the cryosurgery, how would these be managed and by whom?
  • How often will my PSA be checked?
  • What should the PSA be after cryosurgery? What would it mean if it doesn`t reach that level? What would you do then?


Useful web site addresses and support networks

The Continence Foundation www.continence-foundation.org.uk
The Prostate Cancer Charity www.prostate-cancer.org.uk
The Sexual Dysfunction Association www.impotence.org.uk
The Prostate Project www.prostateproject.org

Attention! The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with your physician for further evaluation.

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